1. Overview of capsule filters
The capsule filter is an integrated filtration device that integrates the housing and filter membrane into a compact disposable design. This design cleverly solves the complicated settings and contamination risks in the traditional filtration process. Its working principle is based on the interception effect of the filter membrane. Through the filter membranes of different pore sizes, it can effectively remove particulate impurities, microorganisms and other contaminants in the liquid, thereby ensuring that the purity of the liquid meets the strict requirements of production and experiments.
2. Reasons for choosing capsule filters
Wide range of applications
Cell culture and clarification: In the cell culture process, capsule filters can be used to remove impurities such as cell debris and microorganisms, ensure the purity of cell culture fluids, and create a good environment for cell growth and reproduction. This is essential for the production of high-quality biological products such as monoclonal antibodies and vaccines.
Clarifying fermentation broth/enzyme culture medium: Fermentation broth and enzyme culture medium often contain undissolved solid particles, bacteria and other substances. Capsule filters can efficiently perform clarification treatments to improve the efficiency and product quality of subsequent extraction and purification steps.
Gas sterilization filtration: In some processes that require sterile gas, such as ventilation of fermentation tanks and gas supply of cell culture incubators, capsule filters can perform sterilization filtration on gases to prevent microbial contamination and maintain the sterility of the process environment.
Buffer production and filtration: Taking buffer as an example, capsule filters can accurately remove impurities and microorganisms in buffer, ensure the stability of buffer quality, and meet the strict requirements for buffer purity in biological experiments and production processes.
Outstanding performance advantages
High-efficiency filtration: Capsule filters have a large filtration area and a high flow rate, and can process a large amount of liquid in a short time, improving production efficiency. Its unique structural design makes the filtration process smoother, reduces the residence time of liquid in the filter, and reduces the risk of microbial growth.
Low adsorption: Using special materials and manufacturing processes, the capsule filter has extremely low adsorption to biological molecules such as proteins and nucleic acids, which minimizes the loss of target products and ensures the yield and quality of the product.
Sterility guarantee: As a disposable filtration device, the capsule filter undergoes strict sterilization before leaving the factory, avoiding the cross-contamination problem that may be caused by repeated use, and providing users with reliable sterility guarantee.
3.How to choose a suitable capsule filter
Determine the type according to filtration requirements
Clarification filtration: For clarification filtration processes that need to remove larger particle impurities in liquids, high-efficiency capsule filters or glass fiber capsule filters can be selected. They have larger pore sizes and higher fluxes, and can quickly and effectively remove coarse particle impurities.
Sterilization and microbial load reduction series: In occasions where strict microbial control is required, such as pharmaceutical production, biological experiments, etc., sterilization-grade filters such as hydrophilic capsule filters and high-flow long-life capsule filters are ideal choices. These filters can effectively intercept microorganisms such as bacteria and molds to ensure the sterility of the liquid.
Consider process conditions and parameters
Flow and pressure: Select capsule filters of appropriate specifications according to the flow and pressure requirements of the liquid in the actual process. Ensure that the filter can operate stably within the specified flow and pressure range to avoid poor filtering effect due to overload or insufficient pressure.
Chemical compatibility: Fully consider the chemical properties of the liquid to be filtered and select filter materials that are compatible with it. For example, for strongly acidic liquids, acid-resistant filters should be selected; for organic solvents, ensure that the filter material will not be dissolved or swollen.
